Contribution of genetic factors to platinum-based chemotherapy sensitivity and prognosis of non-small cell lung cancer
Although platinum-based chemotherapy remains the standard treatment for advanced
NSCLC patients, clinical outcomes are poor and most patients develop high-grade toxicities.
Genetic factors, such as single nucleotide polymorphisms (SNPs) involved in platinum
pharmacodynamics, metabolism and mechanism of action, may account for inter-individual
differences shown in effectiveness and toxicity. Polymorphisms in genes involved in DNA
repair and others such as PI3K/PTEN/AKT and TGF-β pathways have been demonstrated to …
NSCLC patients, clinical outcomes are poor and most patients develop high-grade toxicities.
Genetic factors, such as single nucleotide polymorphisms (SNPs) involved in platinum
pharmacodynamics, metabolism and mechanism of action, may account for inter-individual
differences shown in effectiveness and toxicity. Polymorphisms in genes involved in DNA
repair and others such as PI3K/PTEN/AKT and TGF-β pathways have been demonstrated to …
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