[HTML][HTML] Contribution of the Kv3. 1 potassium channel to high-frequency firing in mouse auditory neurones
LY Wang, L Gan, ID Forsythe… - The Journal of …, 1998 - ncbi.nlm.nih.gov
LY Wang, L Gan, ID Forsythe, LK Kaczmarek
The Journal of physiology, 1998•ncbi.nlm.nih.gov… Collectively, our results provide compelling evidence that the Kv3.1 channel enables
auditory neurones to follow high-frequency stimulation. … Based on a strong correlation in
kinetics, voltage dependence and sensitivity to TEA between I HT and homomultimeric Kv3.1
channels in CHO cells, we suggest that I HT represents a population of potassium channels
at least partly comprising Kv3.1 channels, and that this current plays a key role in allowing
these neurones to achieve this rapid repolarization during high-frequency firing. The current …
auditory neurones to follow high-frequency stimulation. … Based on a strong correlation in
kinetics, voltage dependence and sensitivity to TEA between I HT and homomultimeric Kv3.1
channels in CHO cells, we suggest that I HT represents a population of potassium channels
at least partly comprising Kv3.1 channels, and that this current plays a key role in allowing
these neurones to achieve this rapid repolarization during high-frequency firing. The current …
Abstract
1. Using a combination of patch-clamp, in situ hybridization and computer simulation techniques, we have analysed the contribution of potassium channels to the ability of a subset of mouse auditory neurones to fire at high frequencies.
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