Convenient access to new chiral ferroceno-(iso) quinolines
V Mamane, Y Fort - The Journal of Organic Chemistry, 2005 - ACS Publications
V Mamane, Y Fort
The Journal of Organic Chemistry, 2005•ACS PublicationsNew chiral pyridine derivatives possessing the planar chirality of the ferrocene have been
prepared by means of an aldolization− crotonization reaction. This very simple reaction has
been applied to the synthesis of isomers 1− 4 that differ in the position of the nitrogen atom
on the pyridine ring. Following the same procedure, asymmetric synthesis of 1 has been
achieved using an enantiopure ferrocenylzinc intermediate. This method has also allowed
the preparation of a chiral analogue of 2, 2 '-bipyridine.
prepared by means of an aldolization− crotonization reaction. This very simple reaction has
been applied to the synthesis of isomers 1− 4 that differ in the position of the nitrogen atom
on the pyridine ring. Following the same procedure, asymmetric synthesis of 1 has been
achieved using an enantiopure ferrocenylzinc intermediate. This method has also allowed
the preparation of a chiral analogue of 2, 2 '-bipyridine.
New chiral pyridine derivatives possessing the planar chirality of the ferrocene have been prepared by means of an aldolization−crotonization reaction. This very simple reaction has been applied to the synthesis of isomers 1−4 that differ in the position of the nitrogen atom on the pyridine ring. Following the same procedure, asymmetric synthesis of 1 has been achieved using an enantiopure ferrocenylzinc intermediate. This method has also allowed the preparation of a chiral analogue of 2,2‘-bipyridine.
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