Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese …
NA Baker, M Karounos, V English, J Fang… - Environmental …, 2013 - ehp.niehs.nih.gov
Background: Previous studies demonstrated that coplanar polychlorinated biphenyls (PCBs)
promote proinflammatory gene expression in adipocytes. PCBs are highly lipophilic and
accumulate in adipose tissue, a site of insulin resistance in persons with type 2 diabetes.
Objectives: We investigated the in vitro and in vivo effects of coplanar PCBs on adipose
expression of tumor necrosis factor α (TNF-α) and on glucose and insulin homeostasis in
lean and obese mice. Methods: We quantified glucose and insulin tolerance, as well as TNF …
promote proinflammatory gene expression in adipocytes. PCBs are highly lipophilic and
accumulate in adipose tissue, a site of insulin resistance in persons with type 2 diabetes.
Objectives: We investigated the in vitro and in vivo effects of coplanar PCBs on adipose
expression of tumor necrosis factor α (TNF-α) and on glucose and insulin homeostasis in
lean and obese mice. Methods: We quantified glucose and insulin tolerance, as well as TNF …