Copper-catalyzed domino synthesis of multi-substituted benzo [b] thiophene through radical cyclization using xanthate as a sulfur surrogate

N Sundaravelu, T Singha, A Nandy… - Chemical …, 2021 - pubs.rsc.org
Chemical Communications, 2021pubs.rsc.org
The Cu-catalyzed domino synthesis of multi-substituted benzo [b] thiophene through radical
cyclization of 2-iodophenyl ketones was developed using xanthate as a sulfur surrogate.
This method was extended to obtain tetracyclic Lupinalbin analogues through double C–S/C–
O bond formation by changing the substituents. The products were converted to a HTI
photoswitch, benzothiophene-fused flavone.
The Cu-catalyzed domino synthesis of multi-substituted benzo[b]thiophene through radical cyclization of 2-iodophenyl ketones was developed using xanthate as a sulfur surrogate. This method was extended to obtain tetracyclic Lupinalbin analogues through double C–S/C–O bond formation by changing the substituents. The products were converted to a HTI photoswitch, benzothiophene-fused flavone.
The Royal Society of Chemistry
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