From the onset, Corona Virus or COVID-19 has left few people, if any, unaffected. Economies, the world over have been repeatedly tested and stretched. This study was conducted to examine the impact of Corona Virus (Covid-19) on performance of business enterprises in Owerri Municipal Area Imo State, South-East, Nigeria. The study used the Taro Yemmeh formula to determine a sample size of 232 from a population of 430 employees. The mean, standard deviation, and multiple linear regression were used for the analysis and testing of the research hypotheses. Results show that the Covid-19 has a significant negative impact on performance of business enterprises in Owerri Municipal Area of Imo State of Nigeria. The study recommend that Businesses should also explore opportunities focused on becoming more flexible in responding to arising uncertainties. The study concludes that Covid-19 has a significant negative impact on performance of business enterprises in Owerri Municipal Area of Imo State of Nigeria.