Covalent complex of DNA and bacterial topoisomerase: implications in antibacterial drug development
A topoisomerase‐DNA transient covalent complex can be a druggable target for novel
topoisomerase poison inhibitors that represent a new class of antibacterial or anticancer
drugs. Herein, we have investigated molecular features of the functionally important
Escherichia coli topoisomerase I (EctopoI)‐DNA covalent complex (EctopoIcc) for molecular
simulations, which is very useful in the development of new antibacterial drugs. To
demonstrate the usefulness of our approach, we used a model small molecule (SM) …
topoisomerase poison inhibitors that represent a new class of antibacterial or anticancer
drugs. Herein, we have investigated molecular features of the functionally important
Escherichia coli topoisomerase I (EctopoI)‐DNA covalent complex (EctopoIcc) for molecular
simulations, which is very useful in the development of new antibacterial drugs. To
demonstrate the usefulness of our approach, we used a model small molecule (SM) …
[引用][C] Corrigendum: Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development.
Corrigendum: Covalent Complex of DNA and Bacterial Topoisomerase: Implications in
Antibacterial Drug Development. - Abstract - Europe PMC … Corrigendum: Covalent Complex
of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development. …
Antibacterial Drug Development. - Abstract - Europe PMC … Corrigendum: Covalent Complex
of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development. …
以上显示的是最相近的搜索结果。 查看全部搜索结果