intratumoral CD8+ T cell activation. Using multiple strategies, we identified a critical role for
these DC in trafficking tumor antigen to lymph nodes (LN), resulting in both direct CD8+ T
cell stimulation and antigen hand-off to resident myeloid cells. These effects all required
CCR7. Live imaging demonstrated direct presentation to T cells in LN, and CCR7 loss
specifically in these cells resulted in defective LN T cell priming and increased tumor …