Critical role of lipid scramblase TMEM16F in phosphatidylserine exposure and repair of plasma membrane after pore formation
N Wu, V Cernysiov, D Davidson, H Song, J Tang, S Luo… - Cell reports, 2020 - cell.com
Plasma membrane damage and cell death during processes such as necroptosis and
apoptosis result from cues originating intracellularly. However, death caused by pore-
forming agents, like bacterial toxins or complement, is due to direct external injury to the
plasma membrane. To prevent death, the plasma membrane has an intrinsic repair ability.
Here, we found that repair triggered by pore-forming agents involved TMEM16F, a calcium-
activated lipid scramblase also mutated in Scott's syndrome. Upon pore formation and the …
apoptosis result from cues originating intracellularly. However, death caused by pore-
forming agents, like bacterial toxins or complement, is due to direct external injury to the
plasma membrane. To prevent death, the plasma membrane has an intrinsic repair ability.
Here, we found that repair triggered by pore-forming agents involved TMEM16F, a calcium-
activated lipid scramblase also mutated in Scott's syndrome. Upon pore formation and the …
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