Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-κB cistrome to reprogram the prostate cancer cell transcriptome
M Malinen, EA Niskanen, MU Kaikkonen… - Nucleic acids …, 2017 - academic.oup.com
Inflammatory processes and androgen signaling are critical for the growth of prostate cancer
(PC), the most common cancer among males in Western countries. To understand the
importance of potential interplay between pro-inflammatory and androgen signaling for gene
regulation, we have interrogated the crosstalk between androgen receptor (AR) and NF-κB,
a key transcriptional mediator of inflammatory responses, by utilizing genome-wide
chromatin immunoprecipitation sequencing and global run-on sequencing in PC cells. Co …
(PC), the most common cancer among males in Western countries. To understand the
importance of potential interplay between pro-inflammatory and androgen signaling for gene
regulation, we have interrogated the crosstalk between androgen receptor (AR) and NF-κB,
a key transcriptional mediator of inflammatory responses, by utilizing genome-wide
chromatin immunoprecipitation sequencing and global run-on sequencing in PC cells. Co …
Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-ĸB cistrome to reprogram the prostate cancer cell transcriptome
M Marjo - 2016 - erepo.uef.fi
Inflammatory processes and androgen signaling are critical for the growth of prostate cancer
(PC), the most common cancer among males in Western countries. To understand the
importance of potential interplay between pro-inflammatory and androgen signaling for gene
regulation, we have interrogated the crosstalk between androgen receptor (AR) and NF-κB,
a key transcriptional mediator of inflammatory responses, by utilizing genome-wide
chromatin immunoprecipitation sequencing and global run-on sequencing in PC cells. Co …
(PC), the most common cancer among males in Western countries. To understand the
importance of potential interplay between pro-inflammatory and androgen signaling for gene
regulation, we have interrogated the crosstalk between androgen receptor (AR) and NF-κB,
a key transcriptional mediator of inflammatory responses, by utilizing genome-wide
chromatin immunoprecipitation sequencing and global run-on sequencing in PC cells. Co …
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