Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of …
BA Bailey-Elkin, RCM Knaap, GG Johnson… - Journal of Biological …, 2014 - ASBMB
Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging human
pathogen that was first isolated in 2012. MERS-CoV replication depends in part on a virus-
encoded papain-like protease (PL pro) that cleaves the viral replicase polyproteins at three
sites releasing non-structural protein 1 (nsp1), nsp2, and nsp3. In addition to this replicative
function, MERS-CoV PL pro was recently shown to be a deubiquitinating enzyme (DUB) and
to possess deISGylating activity, as previously reported for other coronaviral PL pro …
pathogen that was first isolated in 2012. MERS-CoV replication depends in part on a virus-
encoded papain-like protease (PL pro) that cleaves the viral replicase polyproteins at three
sites releasing non-structural protein 1 (nsp1), nsp2, and nsp3. In addition to this replicative
function, MERS-CoV PL pro was recently shown to be a deubiquitinating enzyme (DUB) and
to possess deISGylating activity, as previously reported for other coronaviral PL pro …
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