Curcumin, the bioactive component of curry spice turmeric, and its related structures
possess potent anti-oxidant and anti-inflammatory properties. Several lines of evidence
suggest that curcumin may play a beneficial role in animal models of diabetes, both by
lowering blood glucose levels and by ameliorating the long-term complications of diabetes.
However, current understanding of the mechanism of curcumin action is rudimentary and is
limited to its anti-oxidant and anti-inflammatory effects. In this study we examine potential …

… Similarly, curcumin treatment did not ameliorate steatosis in oleic acid-treated human
hepatoma Hep3B and rat hepatoma H4IIE cells. Interestingly, curcumin treatment significantly
suppressed hepatic gluconeogenic gene expression, as measured by real-time quantitative
PCR in H4IIE cells. Curcumin treatment (20µM) significantly decreased dexamethasone-induced
phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in H4IIE cells. …