Cyclic adenosine 3′, 5′-monophosphate regulates GLUT4 and GLUT1 glucose transporter expression and stimulates transcriptional activity of the GLUT1 promoter …
We have previously reported that innervation-dependent basal contractile activity regulates
in an inverse manner the expression of GLUT1 and GLUT4 glucose transporters in skeletal
muscle. Based on the facts that muscle innervation decreases and muscle denervation
increases cAMP levels, we investigated whether cAMP might mediate the effects of
innervation/denervation on glucose transporter expression. Treatment of L6E9 myotubes
with 8-bromo-cAMP, forskolin, or monobutyryl-8-bromo-cAMP led to a marked decrease in …
in an inverse manner the expression of GLUT1 and GLUT4 glucose transporters in skeletal
muscle. Based on the facts that muscle innervation decreases and muscle denervation
increases cAMP levels, we investigated whether cAMP might mediate the effects of
innervation/denervation on glucose transporter expression. Treatment of L6E9 myotubes
with 8-bromo-cAMP, forskolin, or monobutyryl-8-bromo-cAMP led to a marked decrease in …
Cyclic adenosine 3', 5'-monophosphate regulates GLUT4 and GLUT1 glucose transporter expression and stimulates transcriptional activity of the GLUT1 promoter in …
F Viñals Canals, J Ferré… - … , 1997, vol. 138, num …, 1997 - diposit.ub.edu
We have previously reported that innervation-dependent basal contractile activity regulates
in an inverse manner the expression of GLUT1 and GLUT4 glucose transporters in skeletal
muscle. Based on the facts that muscle innervation decreases and muscle denervation
increases cAMP levels, we investigated whether cAMP might mediate the effects of
innervation/denervation on glucose transporter expression. Treatment of L6E9 myotubes
with 8-bromo-cAMP, forskolin, or monobutyryl-8-bromo-cAMP led to a marked decrease in …
in an inverse manner the expression of GLUT1 and GLUT4 glucose transporters in skeletal
muscle. Based on the facts that muscle innervation decreases and muscle denervation
increases cAMP levels, we investigated whether cAMP might mediate the effects of
innervation/denervation on glucose transporter expression. Treatment of L6E9 myotubes
with 8-bromo-cAMP, forskolin, or monobutyryl-8-bromo-cAMP led to a marked decrease in …