… cyclic dinucleotides that are released during bacterial infection and in endogenous cyclic …
explanation of the origin of cyclic dinucleotide signalling in mammalian innate immunity. Here …

… In this review, we will use the following conventions to describe other cyclic dinucleotides.
Cyclic ribodinucleotides that contain two identical nucleobases will customarily be …

Cyclic dinucleotides (CDNs) have been previously recognized as important secondary
signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they …

… for the detection of cyclic dinucleotides, which function as … with DNA synthesizes a dinucleotide
molecule that in turn binds to … from previously characterized cyclic dinucleotides. Using a …

Recent advancements in the field of immunotherapy have yielded encouraging results for
the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of …

… almost three decades ago, cyclic dinucleotides (CDNs) have … -AMP and distinct versions of
mixed cyclic GMP-AMP (cGAMP… ubiquity and versatility of cyclic dinucleotide function at the …

… To elucidate the structural basis of cyclic dinucleotide recognition by STING, we have
determined the structure of human STING CTD bound to c-di-GMP at 1.5 Å resolution (Fig. 1d, …

As prophylactic vaccine adjuvants for infectious diseases, cyclic dinucleotides (CDNs)
induce safe, potent, long-lasting humoral and cellular memory responses in the systemic and …

… Here, we demonstrate a prototype of cancer metalloimmunotherapy using cyclic dinucleotide
(CDN) stimulator of interferon genes (STING) agonists and Mn 2+ . We screened various …

… of cyclic dinucleotides and the innate immune signaling. … recognition with exogenous cyclic
dinucleotides from bacterium … differentially to bacterial cyclic dinucleotides. Furthermore, we …