Cyclooxygenase (COX)-1 and -2 Inhibitory Labdane Diterpenes from Crassocephalum mannii
MEF Hegazy, S Ohta, FF Abdel-Latif… - Journal of natural …, 2008 - ACS Publications
MEF Hegazy, S Ohta, FF Abdel-Latif, HA Albadry, E Ohta, PW Paré, T Hirata
Journal of natural products, 2008•ACS PublicationsTwo new labdane diterpenes, 8α, 19-dihydroxylabd-13 E-en-15-oic acid (1) and 13, 14, 15,
16-tetranorlabdane-8α, 12, 14-triol (2), as well as an acetylated derivative, 8α-O-β-d-
glucopyranosyllabd-13 E-ene-15, 19-diol-8α-2′, 3′, 4′, 6′-hexaacetate (3a), were
isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were
elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their
acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.
16-tetranorlabdane-8α, 12, 14-triol (2), as well as an acetylated derivative, 8α-O-β-d-
glucopyranosyllabd-13 E-ene-15, 19-diol-8α-2′, 3′, 4′, 6′-hexaacetate (3a), were
isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were
elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their
acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.
Two new labdane diterpenes, 8α,19-dihydroxylabd-13E-en-15-oic acid (1) and 13,14,15,16-tetranorlabdane-8α,12,14-triol (2), as well as an acetylated derivative, 8α-O-β-d-glucopyranosyllabd-13E-ene-15,19-diol-8α-2′,3′,4′,6′-hexaacetate (3a), were isolated from the aerial parts of Crassocephalum mannii. The structures of 1, 2, and 3a were elucidated by spectroscopic data analysis. Selective inhibitory activity for 1 and 2 and their acetate derivatives, 1a and 2a, against cyclooxygenases (COX-1 and COX-2) was detected.
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