Cytotoxic action of acetate on tumor cells of thymic origin: role of MCT-1, pH homeostasis and altered cell survival regulation
Neoplastic cells display altered biosynthetic and bioenergetic machinery to support cell
survival. Therefore, cancer cells optimally utilize all available fuel resources to pump their
highly upregulated metabolic pathways. While glucose is the main carbon source,
transformed cells also utilize other molecules, which can be utilized in metabolic pathways,
designated as alternative fuels. Acetate is one of such alternative metabolic fuels, which is
mainly consumed in carbohydrate and lipid metabolism. However, studies demonstrate the …
survival. Therefore, cancer cells optimally utilize all available fuel resources to pump their
highly upregulated metabolic pathways. While glucose is the main carbon source,
transformed cells also utilize other molecules, which can be utilized in metabolic pathways,
designated as alternative fuels. Acetate is one of such alternative metabolic fuels, which is
mainly consumed in carbohydrate and lipid metabolism. However, studies demonstrate the …
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