[PDF][PDF] DNA Fusion Vaccines Induce Targeted
HA from a Normal, ESCTL against Minor - J Immunol, 2004 - researchgate.net
We have designed DNA fusion vaccines able to induce high levels of epitope-specific CD8 T
cells, using linked CD4 T cell help. Such vaccines can activate effective immunity against
tumor Ags. To model performance against minor histocompatibility (H) Ags important in
allogeneic hemopoietic stem cell transplantation, responses against the H2Db-restricted Uty
and Smcy male HY epitopes have been investigated. Vaccination of females induced high
levels of tetramer-specific, IFN--producing CD8 T cells against each epitope. Vaccines …
cells, using linked CD4 T cell help. Such vaccines can activate effective immunity against
tumor Ags. To model performance against minor histocompatibility (H) Ags important in
allogeneic hemopoietic stem cell transplantation, responses against the H2Db-restricted Uty
and Smcy male HY epitopes have been investigated. Vaccination of females induced high
levels of tetramer-specific, IFN--producing CD8 T cells against each epitope. Vaccines …
DNA fusion vaccines induce targeted epitope-specific CTLs against minor histocompatibility antigens from a normal or tolerized repertoire
J Rice, S Buchan, H Dewchand, E Simpson… - The Journal of …, 2004 - journals.aai.org
We have designed DNA fusion vaccines able to induce high levels of epitope-specific CD8+
T cells, using linked CD4+ T cell help. Such vaccines can activate effective immunity against
tumor Ags. To model performance against minor histocompatibility (H) Ags important in
allogeneic hemopoietic stem cell transplantation, responses against the H2D b-restricted
Uty and Smcy male HY epitopes have been investigated. Vaccination of females induced
high levels of tetramer-specific, IFN-γ-producing CD8+ T cells against each epitope …
T cells, using linked CD4+ T cell help. Such vaccines can activate effective immunity against
tumor Ags. To model performance against minor histocompatibility (H) Ags important in
allogeneic hemopoietic stem cell transplantation, responses against the H2D b-restricted
Uty and Smcy male HY epitopes have been investigated. Vaccination of females induced
high levels of tetramer-specific, IFN-γ-producing CD8+ T cells against each epitope …
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