DNA replication: metazoan Sld3 steps forward
… However, metazoan Sld2 and Sld3, as well as metazoan S phase CDK targets, remained
elusive. In the last year, three different proteins (DUE-B, Treslin/Ticrr, and GEMC1) were identified
that appear to have similar functions to … In metazoans, Dpb11 most likely corresponds to
TopBP1, but the proteins that function like Sld2 and Sld3 in CMG assembly are not known. Once
assembled, CMG unwinds the origin, leading to binding of the single-stranded … In summary,
the regulation of DUE-B, Treslin/Ticrr, and GEMC1 by CDK is still being elucidated and …
elusive. In the last year, three different proteins (DUE-B, Treslin/Ticrr, and GEMC1) were identified
that appear to have similar functions to … In metazoans, Dpb11 most likely corresponds to
TopBP1, but the proteins that function like Sld2 and Sld3 in CMG assembly are not known. Once
assembled, CMG unwinds the origin, leading to binding of the single-stranded … In summary,
the regulation of DUE-B, Treslin/Ticrr, and GEMC1 by CDK is still being elucidated and …
Summary
In yeast, phosphorylation of the Sld3 protein by cyclin-dependent kinases is essential for replication initiation. In metazoans, three potential Sld3 counterparts have emerged. A new study suggests that one of these, Treslin/Ticrr, is the Sld3 ortholog.
cell.com
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