Deconvolution of compartmental water diffusion coefficients in yeast-cell suspensions using combined T1 and diffusion measurements
An NMR method is presented for measuring compartment-specific water diffusion coefficient
(D) values. It uses relaxography, employing an extracellular contrast reagent (CR) to
distinguish intracellular (IC) and extracellular (EC) 1H2O signals by differences in their
respective longitudinal (T1) relaxation times. A diffusion-weighted inversion-recovery spin-
echo (DW-IRSE) pulse sequence was used to acquire IR data sets with systematically and
independently varying inversion time (TI) and diffusion-attenuation gradient amplitude (g) …
(D) values. It uses relaxography, employing an extracellular contrast reagent (CR) to
distinguish intracellular (IC) and extracellular (EC) 1H2O signals by differences in their
respective longitudinal (T1) relaxation times. A diffusion-weighted inversion-recovery spin-
echo (DW-IRSE) pulse sequence was used to acquire IR data sets with systematically and
independently varying inversion time (TI) and diffusion-attenuation gradient amplitude (g) …
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