Decreased expression of STING predicts poor prognosis in patients with gastric cancer

S Song, P Peng, Z Tang, J Zhao, W Wu, H Li, M Shao… - Scientific reports, 2017 - nature.com
… for gastric cancer. Thus, we aim to explore the function of STING signaling in the development
of gastric cancer… to detect STING expression in 217 gastric cancer patients who underwent …

[HTML][HTML] Prognostic perspectives of STING and PD-L1 expression and correlation with the prognosis of epstein-barr virus-associated gastric cancers

Q Sun, Y Fu, X Chen, L Li, H Wu, Y Liu, H Xu… - Gut and …, 2022 - ncbi.nlm.nih.gov
… showed that decreased expression of STING predicts poor prognosis in GC patients, 19 …
Moreover, when combining analyzed the expression of STING and PD-L1, the patients with …

[HTML][HTML] Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells

L Miao, J Qi, QI Zhao, QN Wu, DL Wei, XL Wei, J Liu… - Theranostics, 2020 - ncbi.nlm.nih.gov
… Methods: We analyzed STING and CD68 expression of 200 pairs of gastric cancerprognostic
values of STING, as well as the correlations between STING and CD68 in gastric cancer. …

Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment

Y Chen, K Jia, Y Sun, C Zhang, Y Li, L Zhang… - Nature …, 2022 - nature.com
… + STING + macrophages were associated with inferior survival. These results aligned with
those reported in previous studies suggesting that STING … negative prognostic value of STING, …

Down-regulation of stimulator of interferon genes (STING) expression and CD8+ T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer

S Fukai, S Nakajima, M Saito, K Saito, K Kase… - Gastric Cancer, 2023 - Springer
… that the low infiltration of CD8 effector T cells in HER2-amplified GC might depend on the
decreased expression of STING. Furthermore, we found that mRNA expression levels of T-cell …

Cancer cell-extrinsic STING shapes immune-active microenvironment and predicts clinical outcome in gastric cancer

Y Wei, Q Ren, P Hu, Y Zou, W Yao, H Qiu - Clinical and Translational …, 2024 - Springer
… A cohort of 154 cases of patients with newly diagnosed gastric cancer were enrolled in
this … , and STING via immunohistochemistry as well as the types and densities of tumor-infiltrating …

[HTML][HTML] STING signaling is a potential immunotherapeutic target in colorectal cancer

HJ Chon, H Kim, JH Noh, H Yang, WS Lee… - … of Cancer, 2019 - ncbi.nlm.nih.gov
… , gastric cancer, and hepatocellular carcinoma, and it is … STING expression was assessed
both in tumor and immune cells. The cut-off values to define high or low expression of STING or …

An analysis of the expression and association with immune cell infiltration of the cGAS/STING pathway in pan-cancer

X An, Y Zhu, T Zheng, G Wang, M Zhang, J Li… - … Therapy-Nucleic Acids, 2019 - cell.com
… that a high level of cGAS/STING signaling predicts a poor prognosis in patients with certain
Decreased expression of STING predicts poor prognosis in patients with gastric cancer. …

Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model

YY Zhong, H Cao, W Li, J Deng, D Li… - Frontiers in …, 2024 - frontiersin.org
STING, and prevents the formation of the STING-TBK1 complex, leading to reduced expression
… CHI3L1 levels were also significantly higher in the serum of patients with gastric cancer

The Expression Patterns of cGAS and STING as Potential Diagnostic Markers in Gastric Cancer

S Hosseinzadeh, E Safarzadeh… - Journal of …, 2022 - pnrjournal.com
… In the present study, we aimed to evaluate the expression patterns of cGAS and STING and
… Gu, Decreased expression of STING predicts poor prognosis in patients with gastric cancer, …