Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021
from northern Uganda, where resistance-associated PfK13 C469Y and A675V mutations
have emerged, and eastern Uganda, where these mutations are uncommon. With the ex
vivo ring survival assay, isolates with the 469Y mutation (median survival 7.3% for mutant,
2.5% mixed, and 1.4% wild type) and/or mutations in Pfcoronin or falcipain-2a, had …
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021
from northern Uganda, where resistance-associated PfK13 C469Y and A675V mutations
have emerged, and eastern Uganda, where these mutations are uncommon. With the ex
vivo ring survival assay, isolates with the 469Y mutation (median survival 7.3% for mutant,
2.5% mixed, and 1.4% wild type) and/or mutations in Pfcoronin or falcipain-2a, had …
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