Deep spatial phenotyping of microglial populations and pathological features in Alzheimer's disease brains using CODEX Multiplexed Imaging
P Sanchez‐Molina, A Pratapa, J Singh… - Alzheimer's & …, 2022 - Wiley Online Library
Background Recent high‐throughput transcriptomics and proteomics analysis have shown a
remarkable heterogeneity of microglia phenotypes across various disease conditions.
Differently from neurons, microglia appearance can be characterized as a continuum
between ramified and amoeboid morphologies. The transcriptional and proteomic profiles
associated to each degree of morphology are potentially multiple and dependent on the
healthy/pathological conditions in consideration with sex, anatomical area of the brain and …
remarkable heterogeneity of microglia phenotypes across various disease conditions.
Differently from neurons, microglia appearance can be characterized as a continuum
between ramified and amoeboid morphologies. The transcriptional and proteomic profiles
associated to each degree of morphology are potentially multiple and dependent on the
healthy/pathological conditions in consideration with sex, anatomical area of the brain and …
[引用][C] Deep spatial phenotyping of microglial populations and pathological features in Alzheimer's disease brains
B Ajami - Alzheimer's Association International Conference, 2024 - alz.confex.com
Alzheimer's Association International Conference …
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