Demethoxycurcumin mediated targeting of MnSOD leading to activation of apoptotic pathway and inhibition of Akt/NF-κB survival signalling in human glioma U87 MG …
Earlier, we reported that Demethoxycurcumin (DMC) suppressed the growth of human
glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we
investigated the DMC induced reactive oxygen species (ROS) mediated anti-proliferative
and apoptotic effects in U87 MG cells. Exposure of U87 MG cells to growth-suppressive
concentrations of DMC (0–50 μg/ml) resulted in ROS generation and concomitant increase
in apoptosis. The major oxidative species induced by DMC was superoxide anion radical (O …
glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we
investigated the DMC induced reactive oxygen species (ROS) mediated anti-proliferative
and apoptotic effects in U87 MG cells. Exposure of U87 MG cells to growth-suppressive
concentrations of DMC (0–50 μg/ml) resulted in ROS generation and concomitant increase
in apoptosis. The major oxidative species induced by DMC was superoxide anion radical (O …
Demethoxycurcumin mediated targeting of MnSOD leading to activation of apoptotic pathway and inhibition of Akt/NF-κB survival signalling in human glioma U87 MG …
RK Rakesh Kumar, NL Neetika Lal… - 2018 - cabidigitallibrary.org
Earlier, we reported that Demethoxycurcumin (DMC) suppressed the growth of human
glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we
investigated the DMC induced reactive oxygen species (ROS) mediated anti-proliferative
and apoptotic effects in U87 MG cells. Exposure of U87 MG cells to growth-suppressive
concentrations of DMC (0-50 µg/ml) resulted in ROS generation and concomitant increase in
apoptosis. The major oxidative species induced by DMC was superoxide anion radical (O2 …
glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we
investigated the DMC induced reactive oxygen species (ROS) mediated anti-proliferative
and apoptotic effects in U87 MG cells. Exposure of U87 MG cells to growth-suppressive
concentrations of DMC (0-50 µg/ml) resulted in ROS generation and concomitant increase in
apoptosis. The major oxidative species induced by DMC was superoxide anion radical (O2 …
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