Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes—the SMART Medea study
L Gerritsen, HC Comijs, Y van der Graaf… - Biological …, 2011 - Elsevier
BACKGROUND: Structural brain changes have often been found in major depressive
disorder (MDD), and it is thought that hypothalamic-pituitary-adrenal (HPA) axis hyperactivity
may explain this relation. We investigated the association of MDD and history of depression
with hippocampal and entorhinal cortex volumes and whether HPA axis activity explained
this association. METHODS: In 636 participants with a history of atherosclerotic disease
(mean age 62±9 years, 81% male) from the second Manifestation of ARTerial disease …
disorder (MDD), and it is thought that hypothalamic-pituitary-adrenal (HPA) axis hyperactivity
may explain this relation. We investigated the association of MDD and history of depression
with hippocampal and entorhinal cortex volumes and whether HPA axis activity explained
this association. METHODS: In 636 participants with a history of atherosclerotic disease
(mean age 62±9 years, 81% male) from the second Manifestation of ARTerial disease …