Deriving dopaminergic neurons for clinical use. A practical approach
R Gonzalez, I Garitaonandia, T Abramihina… - Scientific reports, 2013 - nature.com
R Gonzalez, I Garitaonandia, T Abramihina, GK Wambua, A Ostrowska, M Brock, A Noskov…
Scientific reports, 2013•nature.comNew small molecules that regulate the step-wise differentiation of human pluripotent stem
cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was
found to be the most effective inducer of neural stem cells into dopaminergic neurons. These
neurons are extensively characterized and shown to be functional. We believe this new
approach offers a practical route to creating neurons of sufficient quality to be used to treat
Parkinson's disease patients.
cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was
found to be the most effective inducer of neural stem cells into dopaminergic neurons. These
neurons are extensively characterized and shown to be functional. We believe this new
approach offers a practical route to creating neurons of sufficient quality to be used to treat
Parkinson's disease patients.
Abstract
New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.
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