Desferrioxamine: gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa
M Purro, J Qiao, Z Liu, M Ashcraft… - Chemical …, 2018 - pubs.rsc.org
M Purro, J Qiao, Z Liu, M Ashcraft, MP Xiong
Chemical Communications, 2018•pubs.rsc.orgThe outer membrane of Pseudomonas aeruginosa functions primarily as a permeability
barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe
the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle
that specifically permeabilizes the outer membrane and potentiates antibiotic activity against
P. aeruginosa.
barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe
the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle
that specifically permeabilizes the outer membrane and potentiates antibiotic activity against
P. aeruginosa.
The outer membrane of Pseudomonas aeruginosa functions primarily as a permeability barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle that specifically permeabilizes the outer membrane and potentiates antibiotic activity against P. aeruginosa.
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