Design, microwave assisted synthesis and pharmacological activities of substituted pyrimido [2, 1-b][1, 3] benzothiazole-3-carboxylate derivatives
S Nalawade, V Deshmukh, S Chaudhari - Journal of Pharmacy Research, 2013 - Elsevier
Background and aim The current need for the discovery and development of new lead
compounds exhibiting optimal antitumor potency as well as anti-inflammatory activity. Due to
biological activity of significant number of compounds containing condensed pyrimidine ring
system and our interest in MCRs reactions, we wish to report the synthesis of 4 H-pyrimido
[2, 1-b][1, 3] benzothiazole-3-carboxylate. Method A novel one pot multi-component reaction
of substituted benzaldehyde, ethyl cyanoacetate, 2-amino benzothiazole to give pyrimido [2 …
compounds exhibiting optimal antitumor potency as well as anti-inflammatory activity. Due to
biological activity of significant number of compounds containing condensed pyrimidine ring
system and our interest in MCRs reactions, we wish to report the synthesis of 4 H-pyrimido
[2, 1-b][1, 3] benzothiazole-3-carboxylate. Method A novel one pot multi-component reaction
of substituted benzaldehyde, ethyl cyanoacetate, 2-amino benzothiazole to give pyrimido [2 …
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