Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase
CR Hopkins, M Czekaj, SS Kaye, Z Gao… - Bioorganic & medicinal …, 2005 - Elsevier
CR Hopkins, M Czekaj, SS Kaye, Z Gao, J Pribish, H Pauls, G Liang, K Sides, D Cramer…
Bioorganic & medicinal chemistry letters, 2005•ElsevierA new series of novel mast cell tryptase inhibitors is reported, which features the use of an
indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The
best members of this series display good in vitro activity and excellent selectivity against
other serine proteases.
indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The
best members of this series display good in vitro activity and excellent selectivity against
other serine proteases.
A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.
Elsevier
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