Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide
Designed polymer nanoparticles (NPs) capable of binding and neutralizing a
biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from
combinations of functional monomers. The binding capacity and affinity of the NPs are
individually analyzed. NPs with optimized composition are capable of neutralizing the toxin
even in a complex biological milieu. It is anticipated that this strategy will be a starting point
for the design of synthetic alternatives to antibodies.
biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from
combinations of functional monomers. The binding capacity and affinity of the NPs are
individually analyzed. NPs with optimized composition are capable of neutralizing the toxin
even in a complex biological milieu. It is anticipated that this strategy will be a starting point
for the design of synthetic alternatives to antibodies.
Abstract
Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.
Wiley Online Library以上显示的是最相近的搜索结果。 查看全部搜索结果