This study examined the determinants of brain drain among health workers in public teaching hospitals in Ekiti state. The research design adopted for this study was descriptive survey research design. The population for this study covers all the 3274 staff of public hospitals in Ekiti State. The sample size of the study was 356 staff of public hospitals in Ekiti State gotten by using Taro Yamane formula. The data related to the research work was analyzed using the hierarchical multiple regression. The study revealed that career development has a positive significant effect on brain-drain among health workers in public teaching hospitals in Ekiti State. Also, it was revealed that autonomy has a positive significant effect on brain-drain among health workers in public teaching hospitals in Ekiti State. It was unveiled that, low wages and salaries have a positive significant effect on brain-drain among health workers in public teaching hospitals in Ekiti State. Finally, it was revealed that political instability has a positive significant effect on brain-drain among health workers in public teaching hospitals in Ekiti State. It was therefore recommended that, government should ensure adequate infrastructures and facilities to aid career development in the health sectors. Also, the government should subsidize the cost of schooling for health workers in Nigeria to reduce the rate at which health professional travel out of the country for career and personal development.