Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes

JR Giudicessi, MJ Ackerman - Translational Research, 2013 - Elsevier
JR Giudicessi, MJ Ackerman
Translational Research, 2013Elsevier
Mutations in genes encoding ion channel pore-forming α-subunits and accessory β-subunits
as well as intracellular calcium-handling proteins that collectively maintain the
electromechanical function of the human heart serve as the underlying pathogenic substrate
for a spectrum of sudden cardiac death (SCD)-predisposing heritable cardiac arrhythmia
syndromes, including long QT syndrome (LQTS), short QT syndrome (SQTS), Brugada
syndrome (BrS), and catecholaminergic polymorphic ventricular tachycardia (CPVT). Similar …
Mutations in genes encoding ion channel pore-forming α-subunits and accessory β-subunits as well as intracellular calcium-handling proteins that collectively maintain the electromechanical function of the human heart serve as the underlying pathogenic substrate for a spectrum of sudden cardiac death (SCD)-predisposing heritable cardiac arrhythmia syndromes, including long QT syndrome (LQTS), short QT syndrome (SQTS), Brugada syndrome (BrS), and catecholaminergic polymorphic ventricular tachycardia (CPVT). Similar to many Mendelian disorders, the cardiac “channelopathies” exhibit incomplete penetrance, variable expressivity, and phenotypic overlap, whereby genotype-positive individuals within the same genetic lineage assume vastly different clinical courses as objectively assessed by phenotypic features such electrocardiographic abnormalities and number/type of cardiac events. In this Review, we summarize the current understanding of the global architecture of complex electrocardiographic traits such as the QT interval, focusing on the role of common genetic variants in the modulation of ECG parameters in health and the environmental and genetic determinants of incomplete penetrance and variable expressivity in the heritable cardiac arrhythmia syndromes most likely to be encountered in clinical practice.
Elsevier
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