[PDF][PDF] Determination of (-) α-BISABOLOL in Matricaria chamomile oil and in nanoformulation by HPTLC mhod: it's application in ex vivo studies

Z Naz, MS Faisal, A Muheem, S Singh, JF Ahmad - IAJPR, 2015 - academia.edu
IAJPR, 2015academia.edu
The German chamomile oil, which is commonly known as the blue oil is obtained by the
hydrodistillation of the flower of Matricaria chamomile, family Asteraceae. It mainly consists
of sesquiterpene derivatives (75–90%) that impart blue color to the essential oil [1]. It is
remarkable that chamomile flower oil contains (-)-α-bisabolol, a natural monocyclic
sesquiterpene alcohol (figure 1) obtained as colorless viscous oil as the primary constituent
of the essential oil [2]. It possesses anti-irritant, antiinflammatory and anti-microbial activity …
The German chamomile oil, which is commonly known as the blue oil is obtained by the hydrodistillation of the flower of Matricaria chamomile, family Asteraceae. It mainly consists of sesquiterpene derivatives (75–90%) that impart blue color to the essential oil [1]. It is remarkable that chamomile flower oil contains (-)-α-bisabolol, a natural monocyclic sesquiterpene alcohol (figure 1) obtained as colorless viscous oil as the primary constituent of the essential oil [2]. It possesses anti-irritant, antiinflammatory and anti-microbial activity and is also known to have inhibitory activity on prostaglandins and leukotriene [3, 4]. It is remarkable that chamomile flower oil contains (-)-α-bisabolol, a natural monocyclic sesquiterpenealcohol (figure 1) obtained as colorless viscous oil as the primary constituent of the essential oil [2]. It possesses anti-irritant, anti-inflammatory and anti-microbial activities and is also known to have inhibitory activity on prostaglandins and leukotriene [3, 4].(-)-α-bisabolol inhibited 5-lipoxygenase and cyclooxygenase at an inhibitory concentration of 40 μM and 70-80μM respectively [5]. It is also recommended in cosmetic preparations as an anti-inflammatory compound [6].
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