Determination of Δ9-tetrahydrocannabinolic acid A (Δ9-THCA-A) in whole blood and plasma by LC–MS/MS and application in authentic samples from drivers …

N Raikos, H Schmid, S Nussbaumer, L Ambach… - Forensic science …, 2014 - Elsevier
Abstract Delta-9-tetrahydrocannabinolic acid A (THCA-A) is the biosynthetic precursor of
delta-9-tetrahydrocannabinol (THC) in cannabis plants, and has no psychotropic effects.
THCA-A can be detected in blood and urine, and several metabolites have been identified.
THCA-A was also shown to be incorporated in hair by side stream smoke to a minor extent,
but incorporation via blood stream or sweat seems unlikely. The detection of THCA-A in
biological fluids may serve as a marker for differentiating between the intake of prescribed …
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