Determination of urinary biogenic amines' biomarker profile in neuroblastoma and pheochromocytoma patients by MEKC method with preceding dispersive liquid …
The unbalanced secretion of biogenic amines (BAs) is considered to be a relevant
biochemical biomarker in the screening for neuroendocrine tumors, such as: neuroblastoma
and pheochromocytoma. However, there is still a need to improve the bioanalytical
procedures for BA determination in biological samples due to their instability (photo-and
thermosensitivity, easy oxidation) and low concentration in the body fluids. In this study, the
primary analytical challenge was to optimize the method of extraction of seven compounds …
biochemical biomarker in the screening for neuroendocrine tumors, such as: neuroblastoma
and pheochromocytoma. However, there is still a need to improve the bioanalytical
procedures for BA determination in biological samples due to their instability (photo-and
thermosensitivity, easy oxidation) and low concentration in the body fluids. In this study, the
primary analytical challenge was to optimize the method of extraction of seven compounds …
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