Research in Construction Grammar assumes no strict separation between syntax and the lexicon. However, recent work by Goldberg (1995, 2006) shows that there is indeed a separation between lexical entries and grammatical constructions, including constraints regulating the fusion of grammatical constructions with verbs. This paper argues that Goldberg’s characterization of the interactions between lexical entries and grammatical constructions faces some of the same difficulties as the interactions between lexical entries and transformational rules in the Chomskyan framework (Chomsky, 1965, 1981, 1995). Drawing on a variety of corpus data this paper presents specific proposals that should be considered in order to arrive at a solution that overcomes difficulties inherent to Goldberg’s approach. Based on a discussion of the concepts of analogy, collocational restrictions, frequency, and productivity this paper proposes to encode different types of semantic, pragmatic, and syntactic information in such a way that it is possible to account for a given utterance from a comprehension perspective, as well as a production perspective.