Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies
Olanzapine (OZ) is a second-generation or atypical antipsychotic which selectively binds to
central dopamine D2 and serotonin (5-HT2c) receptors. It has poor bioavailability due to
hepatic first-pass metabolism and low permeability into the brain due to efflux by P-
glycoproteins. The present investigation aimed to prepare a nanoparticulate drug delivery
system of OZ using poly (lactic-co-glycolic acid)(PLGA) for direct nose-to-brain delivery to
provide brain targeting and sustained release. PLGA nanoparticles (NP) were prepared by …
central dopamine D2 and serotonin (5-HT2c) receptors. It has poor bioavailability due to
hepatic first-pass metabolism and low permeability into the brain due to efflux by P-
glycoproteins. The present investigation aimed to prepare a nanoparticulate drug delivery
system of OZ using poly (lactic-co-glycolic acid)(PLGA) for direct nose-to-brain delivery to
provide brain targeting and sustained release. PLGA nanoparticles (NP) were prepared by …
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