Development and validation of an international risk prediction algorithm for episodes of major depression in general practice attendees: the PredictD study
M King, C Walker, G Levy, C Bottomley… - Archives of general …, 2008 - jamanetwork.com
Context Strategies for prevention of depression are hindered by lack of evidence about the
combined predictive effect of known risk factors. Objectives To develop a risk algorithm for
onset of major depression. Design Cohort of adult general practice attendees followed up at
6 and 12 months. We measured 39 known risk factors to construct a risk model for onset of
major depression using stepwise logistic regression. We corrected the model for overfitting
and tested it in an external population. Setting General practices in 6 European countries …
combined predictive effect of known risk factors. Objectives To develop a risk algorithm for
onset of major depression. Design Cohort of adult general practice attendees followed up at
6 and 12 months. We measured 39 known risk factors to construct a risk model for onset of
major depression using stepwise logistic regression. We corrected the model for overfitting
and tested it in an external population. Setting General practices in 6 European countries …
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