A simple isocratic HPLC method has been developed and subsequently validated for simultaneous determination of Telmisartan and Ramipril in pharmaceutical dosage forms. The method employs an Inertsil ODS C18 column, 5 µ, 250mm x 4.60 mm id with flow rate of 1.5 ml/min using PDA detection at 210nm. The separation was carried out using a mobile phase consisting of potassium di hydrogen phosphate buffer having pH 2.8 and Acetonitrile in the ratio of 60: 40 respectively. The retention time for Telmisartan and Ramipril was found to be 5.7 min and 10.8 min respectively. A linear response was observed over the concentration range of 2.5-25.5 ppm and 3.0-7.25 ppm for the assay of Telmisartan and Ramipril respectively. The limit of detection and the limit of quantification for ramipril were found to be 0.75 ppm and 2.5 ppm respectively and for telmisartan were found to be 1.25 ppm and 3.0 ppm respectively. The results of analysis were validated statically and by recovery studies. Hence the proposed method was found to be accurate, precise, reproducible and specific and can be used for simultaneous analysis of these drugs in tablet formulation.