Objective: To develop a simple, rapid, accurate, precise and economical spectroscopic
method for the simultaneous determination of Salbutamol Sulphate, Ambroxol Hydrochloride
and Cetirizine Hydrochloride in combined pharmaceutical tablet formulation and validate as
per ICH guidelines. Methods: In this method, the 6.8 pH phosphate buffer was selected for
the developing spectral characteristics of the three drugs. The overlay spectra of Salbutamol
Sulphate, Ambroxol hydrochloride and Cetirizine hydrochloride were resolved by making …

Objective: Salbutamol sulphate (SBS) and doxophylline (DOX) was used for the treatment of
asthma and bronchitis. In the present study, two simple, accurate, precise, reproducible and
economical UV-spectroscopic methods (A and B) for simultaneous estimation of SBS and
DOX in tablet dosage form have been developed. Methods: In the present study the
simultaneous estimation of SBS and DOX was carried out by two methods. Method A
employs solving of simultaneous equations based on the measurement of absorbance at …