Development of PSMA-targeted and core-crosslinked glycol chitosan micelles for docetaxel delivery in prostate cancer therapy

X Feng, Y Zhou, X Xie, M Li, H Huang, L Wang… - Materials Science and …, 2019 - Elsevier
X Feng, Y Zhou, X Xie, M Li, H Huang, L Wang, X Xu, J Yu
Materials Science and Engineering: C, 2019Elsevier
In this study, prostate-specific membrane antigen (PSMA)-targeted and core-crosslinked
micelles were developed based on prostate cancer-binding peptide (PCP) modified glycol
chitosan-lipoic acid (PGC-LA) conjugate. The degree of substitution was 5.2 PCP groups
and 10.7 lipoic acid groups per 100 sugar residues of glycol chitosan in PGC-LA copolymer.
Docetaxel (DTX) was chosen as a model anti-tumor drug. The DTX-loaded micelles were
prepared by an o/w method, and core-crosslinked micelles were further constructed by using …
Abstract
In this study, prostate-specific membrane antigen (PSMA)-targeted and core-crosslinked micelles were developed based on prostate cancer-binding peptide (PCP) modified glycol chitosan-lipoic acid (PGC-LA) conjugate. The degree of substitution was 5.2 PCP groups and 10.7 lipoic acid groups per 100 sugar residues of glycol chitosan in PGC-LA copolymer. Docetaxel (DTX) was chosen as a model anti-tumor drug. The DTX-loaded micelles were prepared by an o/w method, and core-crosslinked micelles were further constructed by using a catalytic amount of dithiothreitol. The mean diameter of DTX-loaded core-crosslinked PGC-LA (DTX-PGC-LA/cc) micelles was 397 nm determined by dynamic light scattering (DLS). In vitro DTX released from core-crosslinked micelles was slower than that from non-crosslinked counterpart. Blank micelles exhibited good biocompatibility. Additionally, cellular uptake and cytotoxcity of PCP-modified micelles were higher than those of micelles without PCP in PSMA-positive LNCaP cells. Importantly, DTX-PGC-LA/cc demonstrated the stronger anti-tumor efficacy against LNCaP tumor xenograft models than DTX injection and other DTX-loaded micelles. Taken together, this study provides a potential way in developing actively targeted and core-crosslinked micelles for hydrophobic drug delivery in cancer therapy.
Elsevier
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