Development of a flexible microfluidic system integrating magnetic micro-actuators for trapping biological species

R Fulcrand, D Jugieu, C Escriba… - Journal of …, 2009 - iopscience.iop.org
R Fulcrand, D Jugieu, C Escriba, A Bancaud, D Bourrier, A Boukabache, AM Gué
Journal of Micromechanics and Microengineering, 2009iopscience.iop.org
A flexible microfluidic system embedding microelectromagnets has been designed, modeled
and fabricated by using a photosensitive resin as structural material. The fabrication process
involves the integration of micro-coils in a multilayer SU-8 microfluidic system by combining
standard electroplating and dry films lamination. This technique offers numerous
advantages in terms of integration, biocompatibility and chemical resistance. Various
designs of micro-coils, including spiral, square or serpentine wires, have been simulated …
Abstract
A flexible microfluidic system embedding microelectromagnets has been designed, modeled and fabricated by using a photosensitive resin as structural material. The fabrication process involves the integration of micro-coils in a multilayer SU-8 microfluidic system by combining standard electroplating and dry films lamination. This technique offers numerous advantages in terms of integration, biocompatibility and chemical resistance. Various designs of micro-coils, including spiral, square or serpentine wires, have been simulated and experimentally tested. It has been established that thermal dissipation in micro-coils depends strongly on the number of turns and current density but remains compatible with biological applications. Real-time experimentations show that these micro-actuators are efficient in trapping magnetic micro-beads without any external field source or a permanent magnet and highlight that the size of microfluidic channels has been adequately designed for optimal trapping. Moreover, we trap magnetic beads in less than 2 s and release them instantaneously into the micro-channel. The actuation solely relies on electric fields, which are easier to control than standard magneto-fluidic modules.
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