[HTML][HTML] Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro
DJ Smart, FR Helbling, M Verardo, A Huber… - … /Genetic Toxicology and …, 2020 - Elsevier
In vitro genetic toxicology assays are used to assess the genotoxic potential of chemicals or
mixtures. They measure chromosome damage (eg, micronucleus [MN] formation) or gene
mutation, and different combinations of data generated from such assays are evaluated in
concert in order to identify genotoxic hazards. Mode-of-action (MoA) information is also
fundamental to understanding any apparent genotoxic response. In view of the importance
of these types of data for full characterization of genotoxic potential, we leveraged relevant …
mixtures. They measure chromosome damage (eg, micronucleus [MN] formation) or gene
mutation, and different combinations of data generated from such assays are evaluated in
concert in order to identify genotoxic hazards. Mode-of-action (MoA) information is also
fundamental to understanding any apparent genotoxic response. In view of the importance
of these types of data for full characterization of genotoxic potential, we leveraged relevant …
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