Electrospinning fabricates nano dimensional fibers exhibiting characteristics such as tunable porosity, high surface to volume ratio and the ability to incorporate biocompatible materials in nano fibrous polymeric structures. The ease of fiber functionalization, economic viability and deposition of electro-spun fibers on variety of substrates has made electrospinning sought-after technique in the biomedical field. The applicability of bio-adaptable nanoscale electro-spun fibers is evident in tissue engineering, drug delivery, vascular grafts, implants and neural prostheses, bio-sensing and a plethora of other applications. This review summarizes types and parameters of electrospinning techniques essential for generating highly functional biocompatible nanofibers in future of bio-medicine.