[HTML][HTML] Diabetes enhances the efficacy of AAV2 vectors in the retina: therapeutic effect of AAV2 encoding vasoinhibin and soluble VEGF receptor 1
N Díaz-Lezama, Z Wu, E Adán-Castro, E Arnold… - Laboratory …, 2016 - Elsevier
Adeno-associated virus (AAV) vector-mediated delivery of inhibitors of blood–retinal barrier
breakdown (BRBB) offers promise for the treatment of diabetic macular edema. Here, we
demonstrated a reversal of blood–retinal barrier pathology mediated by AAV type 2 (AAV2)
vectors encoding vasoinhibin or soluble VEGF receptor 1 (sFlt-1) when administered
intravitreally to diabetic rats. Efficacy and safety of the AAV2 vasoinhibin vector were tested
by monitoring its effect on diabetes-induced changes in the retinal vascular bed and …
breakdown (BRBB) offers promise for the treatment of diabetic macular edema. Here, we
demonstrated a reversal of blood–retinal barrier pathology mediated by AAV type 2 (AAV2)
vectors encoding vasoinhibin or soluble VEGF receptor 1 (sFlt-1) when administered
intravitreally to diabetic rats. Efficacy and safety of the AAV2 vasoinhibin vector were tested
by monitoring its effect on diabetes-induced changes in the retinal vascular bed and …
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