Merkel cell carcinoma (MCC) is a rare tumour of the skin of neuro-endocrine origin probably
developing from neuronal mechanoreceptors. A collaborative group of multidisciplinary
experts form the European Dermatology Forum (EDF), The European Association of
Dermato-Oncology (EADO) and the European Organization of Research and Treatment of
Cancer (EORTC) was formed to make recommendations on MCC diagnosis and
management, based on a critical review of the literature, existing guidelines and expert's …

Merkel cell carcinoma (MCC) is a rare skin cancer, accounting for less than 1% of all
cutaneous malignancies. It is found predominantly in white populations and risk factors
include advanced age, ultraviolet exposure, male sex, immunosuppression, such as
AIDS/HIV infection, haematological malignancies or solid organ transplantation, and Merkel
cell polyomavirus infection. MCC is an aggressive tumour with 26% of cases presenting
lymph node involvement at diagnosis and 8% with distant metastases. Five-year overall …