DiamondGAN: unified multi-modal generative adversarial networks for MRI sequences synthesis

H Li, JC Paetzold, A Sekuboyina, F Kofler… - … Image Computing and …, 2019 - Springer
Medical Image Computing and Computer Assisted Intervention–MICCAI 2019: 22nd …, 2019Springer
Synthesizing MR imaging sequences is highly relevant in clinical practice, as single
sequences are often missing or are of poor quality (eg due to motion). Naturally, the idea
arises that a target modality would benefit from multi-modal input, as proprietary information
of individual modalities can be synergistic. However, existing methods fail to scale up to
multiple non-aligned imaging modalities, facing common drawbacks of complex imaging
sequences. We propose a novel, scalable and multi-modal approach called DiamondGAN …
Abstract
Synthesizing MR imaging sequences is highly relevant in clinical practice, as single sequences are often missing or are of poor quality (e.g. due to motion). Naturally, the idea arises that a target modality would benefit from multi-modal input, as proprietary information of individual modalities can be synergistic. However, existing methods fail to scale up to multiple non-aligned imaging modalities, facing common drawbacks of complex imaging sequences. We propose a novel, scalable and multi-modal approach called DiamondGAN. Our model is capable of performing flexible non-aligned cross-modality synthesis and data infill, when given multiple modalities or any of their arbitrary subsets, learning structured information in an end-to-end fashion. We synthesize two MRI sequences with clinical relevance (i.e., double inversion recovery (DIR) and contrast-enhanced T1 (T1-c)), reconstructed from three common sequences. In addition, we perform a multi-rater visual evaluation experiment and find that trained radiologists are unable to distinguish synthetic DIR images from real ones.
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