Diastereoselective Synthesis of 2, 6‐Diaryltetrahydrothiopyran‐4‐ones by Phase‐Transfer Catalysis

T Gendron, H Kessedjian… - European Journal of …, 2015 - Wiley Online Library
T Gendron, H Kessedjian, E Davioud‐Charvet, DA Lanfranchi
European Journal of Organic Chemistry, 2015Wiley Online Library
Two efficient phase‐transfer‐catalyzed protocols for the diastereoselective synthesis of cis
and trans isomers of 2, 6‐diaryltetrahydrothiopyran‐4‐ones (2, 6‐DATHTPs) have been
developed. In a study of the scope of the reactions, differently substituted 2, 6‐DATHTPs
were successfully accessed in high yields and diastereomeric excessses on both
experimental and preparative scales.
Abstract
Two efficient phase‐transfer‐catalyzed protocols for the diastereoselective synthesis of cis and trans isomers of 2,6‐diaryltetrahydrothiopyran‐4‐ones (2,6‐DATHTPs) have been developed. In a study of the scope of the reactions, differently substituted 2,6‐DATHTPs were successfully accessed in high yields and diastereomeric excessses on both experimental and preparative scales.
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