Differences in protein concentration dependence for nucleation and elongation in light chain amyloid formation
Light chain (AL) amyloidosis is a lethal disease characterized by the deposition of the
immunoglobulin light chain into amyloid fibrils, resulting in organ dysfunction and failure.
Amyloid fibrils have the ability to self-propagate, recruiting soluble protein into the fibril by a
nucleation–polymerization mechanism, characteristic of autocatalytic reactions.
Experimental data suggest the existence of a critical concentration for initiation of fibril
formation. As such, the initial concentration of soluble amyloidogenic protein is expected to …
immunoglobulin light chain into amyloid fibrils, resulting in organ dysfunction and failure.
Amyloid fibrils have the ability to self-propagate, recruiting soluble protein into the fibril by a
nucleation–polymerization mechanism, characteristic of autocatalytic reactions.
Experimental data suggest the existence of a critical concentration for initiation of fibril
formation. As such, the initial concentration of soluble amyloidogenic protein is expected to …
[引用][C] Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation
M Pinaki, RA Marina - 2017
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