Enhancers are context-specific regulators of expression that drive biological complexity and
variation through the redeployment of conserved genes. An example of this is the enhancer-
mediated control of the transcription of Engrailed 1 (EN1), a pleiotropic gene whose
expression is required for the specification of eccrine sweat glands in mammals. We have
previously identified an enhancer, ECE18 that has been highly and repeatedly derived on
the human lineage to potentiate ectodermal EN1 and induce our species' uniquely high …

Enhancers are context-specific regulators of expression that drive biological complexity and
variation through the redeployment of conserved genes. An example of this is the enhancer-
mediated control of Engrailed 1 (EN1), a pleiotropic gene whose expression is required for
the formation of mammalian eccrine sweat glands. We previously identified the En1
candidate enhancer (ECE) 18 cis-regulatory element that has been highly and repeatedly
derived on the human lineage to potentiate ectodermal EN1 and induce our species' …