… Although the literature does not provide a comprehensive list of “difficult peptides”, below
we refer to some that fit the description and that have been synthesized or whose β-sheet …

… difficulties in synthesis by assembling onto the solid support, instead of the difficult peptide
itself, … This is built by extending the peptide chain, from a suitable point on, via the β-hydroxyl …

… This observation resulted in the development of peptide synthesis reagents that are … substantial
improvements in the synthetic outcome of difficult peptides. These reagents include the 2-…

… Alternatively, difficult peptides may be obtained by the synthesis of depsipeptide (also named
O-peptide, or O-acyl isopeptide) analogs 51,52,53 . In a depsipeptide, the tendency toward …

… 26-mer 1 represented a ‘difficult’ peptide sequence in that an … peptide. On the other hand
substitution of the acid fluoride-forming reagent TFFH 3 for N-TBTU gave the desired peptide …

… of synthetic difficulties. The principles underlying the occurrence of difficult peptide sequences
… is that aggregation occurs resulting in poor solvation within the peptide-polymer matrix. …

… Thus the corresponding 10-mer analogue [(Leu 6 )JR 10-mer (H-WFTTLLSTIG-OH)] should
also be a difficult peptide as an excellent short model for the testing of our methodology. In …

… much more correct synthesis of “difficult” peptides that we could not obtain in good purity and
even could not obtain at all (peptides 86–88, 90, 91) with the help of the standard schedule. …

… such difficult sequences and is tested by its successful application to 101 previously performed
solid-phase peptide … the solid-phase synthesis of peptides containing difficult sequences. …

… co-workers for peptides that form strong inter- or intra molecular, non-covalent interactions
which form insoluble peptide aggregates. “Difficult sequences” are peptide sequences that …